4-ACO-DMT, O-Acetylpsilocin is a semi-synthetic psychoactive drug that has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies, as they are both believed to be prodrugs of psilocin.
As a novel psychoactive compound, 4-AcO-DMT exists in a legal grey area in many countries. In some countries, the substance is legal while in others it is explicitly illegal.
4-AcO-DMT (or psilacetin) is a semi-synthetic tryptamine closely related to the psychedelic mushroom molecules psilocin and psilocybin. But it’s also available in pills, tablets, capsules, and gel tabs among other preparations.
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How 4-AcO-DMT Causes A Psychedelic Experience
4-AcO-DMT is a structural analog of the psychedelic compound psilocybin, meaning they both have a similar chemical structure.
Like psilocybin, it is thought that 4-AcO-DMT acts as a prodrug to psilocin, meaning that when the body processes it, it breaks down into psilocin, which is responsible for magic mushrooms’ subjective effects. The psychedelic researcher David E. Nichols suggested this in 1999.
The History of 4-AcO-DMT
Albert Hofmann and Franz Troxler first synthesized 4-AcO-DMT in the early 1960s. Sandoz, a Swiss chemical company that produced LSD (discovered by Hofmann), then patented 4-AcO-DMT in 1963. However, its subjective effects were not investigated at the time.
It is currently unknown when people first started using 4-AcO-DMT and exploring its psychedelic effects. Its recreational use peaked in the 2010s, which is when the drug appeared on the online research chemical market.
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Differences Between 4-Aco-DMT And Psilocybin
Despite many people claiming 4-AcO-DMT offers an identical experience to psilocybin mushrooms, others say there are differences between the two. And this could come down to the fact that these mushrooms contain other psychoactive compounds, not just psilocybin. Indeed, consuming magic mushrooms is very different from ingesting pure psilocybin by itself (which occurs pretty much exclusively in clinical trials).
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