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Liquid ketamine, Ketamine is a rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant.
Ketamine interacts with N-methyl-D-aspartate (NMDA) receptors, opioid receptors, monoaminergic receptors, muscarinic receptors and voltage sensitive Ca ion channels. Unlike other general anaesthetic agents, ketamine does not interact with GABA receptors.
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Ketamine is highly associated with developing ulcerative cystitis, a form of panful bladder syndrome characterized by damage to the bladder’s tissues leading to chronic, recurring pelvic pain, with ulcers – red, bleeding patches – in the walls of the bladder. According to the Interstitial Cystitis Association, about 5 percent of people with interstitial cystitis, whether it is ulcerative or not, develop end-stage cystitis. This condition is a failure of the bladder, leading to an organ that is hard, extremely painful, and unable to hold urine
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Also, esketamine is only part of the treatment for a person with depression. To date, it has only been shown to be effective when taken in combination with an oral antidepressant. For these reasons, esketamine is not considered a first-line treatment option for depression. It’s only prescribed for people with moderate to severe major depressive disorder who haven’t been helped by at least two other depression medications.
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