5-MeO-DMT

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5-meo-dmt kaufen, 5-MeO-DMT or O-methyl-bufotenin is a psychedelic of the tryptamine class. It is found in a wide variety of plant species, and also is secreted by the glands of at least one toad species, the Sonoran Desert toad. Like its close relatives DMT and bufotenin, it has been used as an entheogen in South America.

 

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5-Methoxy-N,N–dimethyltryptamine (5-MeO-DMT) belongs to a group of naturally-occurring psychoactive indolealkylamine drugs. It acts as a nonselective serotonin (5-HT) agonist and causes many physiological and behavioral changes. 5-MeO-DMT is O-demethylated by polymorphic cytochrome P450 2D6 (CYP2D6) to an active metabolite, bufotenine, while it is mainly inactivated through the deamination pathway mediated by monoamine oxidase A (MAO-A). 5-MeO-DMT is often used with MAO-A inhibitors such as harmaline.

 

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It is distributed in a wide variety of plant species as well as in the venom of a single toad species (Bufo Alvaris). Although little is known about its history, it is believed to have been used in South American shamanic practices for centuries. In modern times, both the extracts of the toad venom as well as synthetic powder form are used, primarily via vaporization.

 

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5-MeO-DMT Treatment

Animals anesthetized with isoflurane (3%–5% L/min for induction and 1%–3% L/min for maintenance; Gargiulo et al., 2012) received a single ICV injection of 1 μL 5-MeO-DMT solution (100 μg 5-MeO-DMT in 10% DMSO/90% saline) prepared fresh (Commissaris and Davis, 1982; DeVos and Miller, 2013).

 

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Chemistry

5-MeO-DMT or 5-methoxy-N,N-dimethyltryptamine is a ring-substituted indole alkaloid molecule of the tryptamine class. 5-MeO-DMT is substituted at R₅ of its indole heterocycle with a methoxy (MeO) functional group CH₃O−; it also contains two methyl groups CH₃– bound to the terminal amine R_N of its tryptamine backbone (DMT).

5-MeO-DMT is the N-substituted methyl homologue of 5-MeO-MiPT and 5-MeO-DiPT, although it radically differs in its effects

 

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